Aggregation sickle hemoglobin

Abstract

Sickle cell disease is a single-cell mutation gene disorder with a substitution of glutamine to valine at the sixth amino acid position in the beta chain hemoglobin. The mutation causes the body to make abnormal hemoglobin that causes the red blood cells to form a crescent shape that is rigid, sticky, and has a lack of iron and oxygen to carry from the lungs to remain parts of the body. Due to the sickle cell mutation, a patient experiences: chronic anemia, chronic damage to organs, episodes of acute pain, priapism, swelling in the hands and feet, delayed growth or puberty, and reduced life expectancy.