Aggregation of magnetic chitosan based nanoparticles and their application in controlled drug release

Abstract

Novel less than 100 nm sized magnetic Co0.5Mn0.5Fe2O4-chitosan nanoparticles advantageous in respect of excellent biodegradation and high level of controllability are successfully prepared. TEM and SEM images showed the cubic-shape magnetic Co0.5Mn0.5Fe2O4 particles were encapsulated by spherical chitosan nanoparticles. The release behavior of bovine serum albumin entrapped in the particles was of distinctly difference with the changes of pH value of loading medium. The release of bovine serum albumin in those two kinds of particles in the medium of pH=1.0 was much quicker in pH = 7.4 and 9.18. The amount of Bovine serum albumin (BSA) released from the particles at different time intervals was estimated using UV spectrophotomertic method at 279 nm. The dissolution profile and in vitro release kinetics showed that Co0.5Mn0.5Fe2O4-chitosan nanoparticles were promising for controlled delivery of the drug.