Abstract
Aggregation of Gold Nanoparticles for Spectrophotometric Determination of Bisoprolol Hemifumarate, Buspirone HCl and Doxazosin Mesylate
Highlights
Bisoprolol hemifumarate is (RS)-1-[4-[[2-(1Methylethoxy) ethoxy] methyl] phenoxy]-3-[(1methylethyl) amino] propan-2-ol fumarate
Gold NPs influence the absorbance spectra due to the surface plasmon resonance (SPR) that occurs when electron field around NP oscillates due to the light energy being absorbed by the same field
This effect is influenced by the NP size and shapes [25]; the aggregation state of gold NPs has an effect on their optical properties
Summary
Bisoprolol hemifumarate is (RS)-1-[4-[[2-(1Methylethoxy) ethoxy] methyl] phenoxy]-3-[(1methylethyl) amino] propan-2-ol fumarate. Bisoprolol hemifumarate is official, and can be determined in British Pharmacopoeia (BP) [2a] by nonaqueous titration using perchloric acid and in United States Pharmacopoeia (USP) [3a] by high performance liquid chromatography (HPLC) method. Buspirone HCl is 8-[4-[4-(Pyrimidin-2-yl) piperazin-1-yl] butyl]-8-azaspiro [4.5] decane-7,9dione hydrochloride. It is an anxiolytic agent from the azapirone class of compounds [1b]. Buspirone hydrochloride is official and can be determined in BP http://www.nanobe.org [2b] by non-aqueous titration with perchloric acid; it is official in USP [3b] which reports HPLC method for its assay. Various analytical methods have been employed for its determination in raw material, pharmaceuticals and biological fluids These methods include chromatography [10], spectrofluorimetry [11] and spectrophotometry [12,13,14]
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