Abstract
Background: CystatinC (CysC) is an endogenous cysteine protease inhibitor, and expressed in all nucleated cells. This protein is mainly localized in lysosome, but is also secreted in body fluids. L68Q mutation of CysC increases its amyloid aggregation property, leading to Hereditary CysC Cerebral Amyloid Angiopathy. Moreover, CysC is known as a major component of Bunina bodies, an ALS-specific neuronal inclusion body, suggesting its relationship with neurodegeneration.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
