Abstract
Germinal vesicle (GV) transfer, spindle-chromosome complex transfer in MII oocytes and two pronuclei transfer have been evaluated as possible treatments for patients who have mitochondrial disease. However, GV transfers often lead to heteroplasmy while the other two methods are frequently associated with aneuploidy. In the present study we have used a new method based on the transfer of aggregated chromosomes (ACs), which can be observed in human oocytes before the metaphase spindle is established.
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