Abstract
C3H mice were injected with C57L spleen cells and 24 hours later with sheep erythrocytes. Recipients of spleen cells from C57L donors previously injected with C3H tissue developed lower antisheep hemagglutinin titers than control mice. Neither donor serum nor saline extracts of lyophilized donor spleen cells had significant cytotoxicity demonstrable in vitro. However, both heat-killed spleen cells and lyophilized spleen cells injected in vivo had a depressant effect on the anti-sheep hemagglutinin titer. The depressant effect is attributed to isoimmunization of the spleen cell donors since injection of spleen cells from donors not previously exposed to C3H antigens did not result in a lowered antisheep hemagglutinin titer.
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