Abstract
The granulosis virus (GV) of the Indian meal moth, Plodia interpunctella (Hübner), was found to agglutinate several species of vertebrate erythrocytes with differential specificity. Optimal conditions for hemagglutination of rabbit cells were established and used to study interactions between GV and vertebrate cells. Electron microscopy and hemagglutination-inhibition studies indicated that aggregated enveloped nucleocapsids were involved in the agglutination phenomenon. Enzymatic treatments of erythrocytes suggested that GV interacted with neuraminidase and trypsin-sensitive cell membrane components. Furthermore, binding studies demonstrated that adsorption of 125I-labeled GV to cells occurred not only under acidic conditions but also under alkaline conditions where hemagglutination was not observed. It is believed that although GV binds to cells under both acidic and alkaline conditions, hemagglutination is facilitated by aggregation of GV at low pH.
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