Abstract
Stoichiometric hydroxyapatite (HAP) is a prominent biomaterial, notably used as coating on metal bone prostheses. High chemical purity and a specific particle size distribution are the main properties for such an application. Based on industrial practice, a reference synthesis was first performed in a lab-scale stirred reactor. Improvements were then suggested by varying the physicochemical and hydrodynamic conditions. The shear rate within the reactor, characterized by the mean Kolmogorov micro-scale, has a strong impact on the final agglomerate size distribution. By maintaining a rather high mixing rate and a high temperature, the duration of the synthesis can be reduced considerably without affecting the HAP purity provided the pH is properly regulated. This consists of imposing acidic conditions during a short period just after the initial formation of large aggregates and then setting the pH at above 7.5 to ensure the production of pure stoichiometric HAP.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
