Ag/Fe3O4/TiO2@MWCNTs as a reusable organometallic nanocatalyst promoted green synthesis of new pyridobenzoazepines: Study of biological activity and reduction of organic pollutants

Abstract

AbstractIn this research, we synthesized the Ag/Fe3O4/TiO2@MWCNTs magnetic nanocomposites using water extract of Spinacia oleracea leaves, and the high performance of synthesized catalyst was confirmed by employing it in the multicomponent reaction of isatoic anhydride, N‐methylimidazole, α‐haloketones, electron‐deficient acetylenic compounds, ammonium acetate, and methyl epoxide in water at ambient temperature for the preparation of new pyridobenzoazepine derivatives in high yields. Also, the catalytic activity of the green synthesized Ag/Fe3O4/TiO2@MWCNTs was evaluated in the reduction of organic pollutants such as 4‐nitrophenol (4‐NP) in water at mild conditions. The results indicated that the biosynthesized magnetic nanocomposites (MNCs) have very high and effective catalytic activity for organic pollutants within few seconds. The synthesized compounds have OH group in their structure and for this reason maybe show good antioxidant activity. Also, employing Gram‐positive and Gram‐negative bacteria in the disk diffusion procedure confirmed antimicrobial effect of the some pyridobenzoazepine derivatives. The results showed that synthesized compounds prevented the bacterial growth. This used procedure for preparation of pyridobenzoazepine derivatives have some advantages such as low reaction time, product with high yields, and simple separation of catalyst and products.