Abstract
1. 1. Total content of DNA and RNA in liver, kidney and spleen were measured in young and aged rats. At the same time the incorporation of [ 14C]thymidine, a DNA precursor, and [ 3H]uridine, an RNA precursor, were also determined. 2. 2. Changes in total organ DNA and RNA correlated with sexual maturation as did incorporation of precursors. 3. 3. Young animals have more DNA per organ relative to RNA. with kidney and spleen DNA showing a decrease between maturity and senescence. 4. 4. However, liver RNA increases with age. a change probably due to decreased catabolism of RNA since [ 3H]uridine uptake decreases. 5. 5. Liver polyploid differentiation, and [ 14C]thymidine and [ 3H]uridine uptake, are correlated. 6. 6. In kidney, incorporation of [ 3H]uridine is inversely related to [ 14C]thymidine incorporation.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
