Abstract
The population of stromal precursors in the femoral marrow, spleen, and thymus was determined by monolayer culture of hematopoietic and lymphoid tissue in guinea pigs of different ages. The number of clonogenic stromal precursor cells was found to depend on the animals' age. It reached a maximum in the femoral marrow and spleen after 2 months, thereafter it remained unchanged with age in the spleen, but decreased significantly in the bone marrow. In the period of active function of the thymus the population of its stromal precursors remained relatively constant, but in old guinea pigs no stromal precursors were present.
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