Abstract
AbstractSeveral definitive statements concerning the effect(s) of animal age on liver drug metabolism are made, and at the same time certain crucial questions that remain to be resolved are posed. Between 16 and 30 months of age, or maturity and senescence, the male Fischer rat exhibits a significant loss of hepatic smooth-surfaced endoplasmic reticulum (SER) which constitutes a real quantitative change. However, this does not exclude the possibility of qualitative age-related changes in this membrane, such as compositional alterations which may be reflected in its functional integrity. Second, there is a significant decline in the noninduced activities or amounts of enzymes and hemoproteins, respectively, of the microsomal mixed function oxidase system. With the exception of the loss of cytochrome P-450, which represents a quantitative change, the age-dependent alterations in the two enzymes may reflect quantitative and/or qualitative changes. Last, the reduced hepatic responsiveness to phenobarbital is ...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
