Age-related cataract in patients with impaired purine metabolism

Abstract

The age-related cataract is multifactorial pathology however, all aspects of its development are still remaining today to be fully unexplored. This report uncovers for the first time the connection age-related cataract with abnormal purine metabolism, which we had discovered. The aim. The main idea of the research was to study this connection as one of the factors of etiology and pathogenesis. Material and methods. The patients were divided into two groups: first group - patients with age-related without hyperuricemia and normal uric acid in the urine daily, the second group - patients with age-related associated with hyperuricemia, patients of the second group was subdivided into two subgroups: subgroup a patients suffering from age-related associated with hyperuricemia with normal uric acid in the urine daily; subgroup B - patients suffering from age-related associated with hyperuricemia with low content of uric acid in the urine daily. Results. As a result of which it was revealed that the patients in the hyperuricemia group were identified large severity of symptoms of age-related cataract during biomicroscopy and intraoperative action in comparison with the group of patients without hyperuricemia. In the group of patients having hyperuricemia and lower content of uric acid in daily urine it was found brown opacity of the lens core during the biomicroscopy, more dense lens and badly crushing cortical masses during intraoperative action in comparison with the group of patients having age-related cataract and not associating with abnormal purine metabolism and the group of patients having hyperuricemia and normal concentration of uric acid in daily urine. Conclusion. The result we achieved can be classified the age-related cataract as hyperuricemia - associated diseases.