Abstract

Agenesis of the Corpus Callosum: Magnetic Resonance Imaging in Antenatal and Postnatal Cases

Highlights

  • Agenesis of the corpus callosum (ACC) is a birth defect manifested by the complete absence of the corpus callosum, due to a disruption of the brain cell migration during the fetal development of a child

  • Genetic factors are considered to be the main cause of ACC

  • The complete corpus callosum agenesis is a frequent anomaly commonly associated with other anomalies and anatomical lesions of the brain

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Summary

Introduction

Agenesis of the corpus callosum (ACC) is a birth defect manifested by the complete absence of the corpus callosum, due to a disruption of the brain cell migration during the fetal development of a child. ACC can be an isolated disorder, it is frequently associated with other anomalies and neuro anatomical lesions such as the aneuploidy and non-aneuploidy syndromes, other CNS associations, as well as inborn errors of the metabolism [1]. It is estimated that the frequency ranges between 0.5 and 70 in 10,000 birth or adult population [2] and is higher in pediatric cases with development anomalies (230 in 10,000 ) or it can reach 2-3 per 100 birth [3]. In cases with isolated ACC, clinical syndromes are divers and vary in the severity of the clinical picture. Matteo Chiappedi et al [6] described a case harboring the isolated ACC who has had mild learning difficulties with preserved intelligence

MRI appearance of ACC
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