AgeLOC Vitality enhances sexual functions in normal and impotent models

Abstract

Based on the differentiated gene expression in skeletal muscle and brain tissue between the young (5 mo) and old (25 mo) mice, ageLOC Vitality was formulated with ingredients (Cordyceps sinensis Cs‐4 and extracts from ginseng and pomegranate) that oppose the age associated changes. Previously we reported that it improved maximal/endurance exercise, glucose metabolism, anti‐oxidation and mitochondria functions in old mice (FASEB J. 2011 25:1114.9; 1049.2). In this study we examined its effect on sexual functions in rats and mice. (1) Rats (3 mo) underwent orchiectomy (OE), resulting in prolongation of erection latency (EL) (p<0.01). After >5 wks of rest, OE rats received 3 days of vehicle or Vitality at 0.2 or 0.8 g/kg by gavage. Vitality shortened EL in OE rats that received a single dosing at both dosages of Vitality and after 3 days at 0.8 g/kg, compared to OE controls (p<0.01). (2) ICR mice (8 mo) received Vitality at 0.4 or 0.8 g/kg for 20 days and were examined for capture latency (CL) and capture times within 20 min (CT20). There were no significant changes in plasma Dihydrotestosterone or Follicle‐Stimulating Hormone on Day 20, compared to controls. CL was shortened with Vitality 0.4 g/kg (p=0.03). CT20 was increased by 78% on Day 3 at 0.4 g/kg (p<0.01), and 109% on Day 20 at 0.8 g/kg (p<0.01). In conclusion: ageLOC Vitality enhances sexual behavior by shortening EL in OE rats, and by shortening CL and increasing CT20 in mice.