Abstract
The fundamental concepts of the aging process are exposed: Its dimension as a health problem, aspects related to its repercussion from the social point of view, and Its influence on aspects that can affect the normal development of contemporary society. The roles of genetics, cellular and biochemical processes that concur in the development of aging is analyzed, making special reference to the role of Adenosine Mono Phosphate Kinase [AMPK]. activation in the regulation of the aging process and the participation of mechanisms for its activation. It is concluded that Policosanol is a medicament of natural origin that could be proposed as candidate to be used for a healthy aging, based on the results of various investigations in experimental models and data obtained from different clinical trials.
Highlights
Taking into account that the improvement in the functionality of High-Density Lipoprotein- Cholesterol (HDL-c) is associated with the effects of cell regeneration, vasodilation, anti-thrombotic and anti-apoptotic and that policosanol notably increases the concentration of plasmalogen and paraoxonase in HDL-c; a study was carried out where an increase in the growth rate of brain gliomas cells and the regeneration of the tail was observed in an experiment with zebrafish treated with reconstituted HDL-c and enriched with policosanol
Antioxidant effects When Policosanol is administered orally (100 and 200 mg / kg) to rats, a decrease in lipid peroxidation is observed in the serum of these animals for 4 weeks; thiobarbituric acid formation in microsomes isolated from rats is significantly decreased by 50%; decreases hyperlipidemia as well as oxidative stress in KKA mice with type II diabetes as well as significantly increases (20.9%) the latency time to initiate Cu +2-induced LDL peroxidation, while increasing total antioxidant activity plasma (24.2%) (p
The increase in the global population over 60 years of age and the communicable diseases (CNCDs) associated with the increase in life expectancy are a cause for concern throughout the world
Summary
That is because aging results a state of vulnerability to worsening conditions related to climate change, emerging infectious diseases or infectious diseases resistant to antibiotics, but above all, due to the increasing incidence of chronic non-communicable diseases (CNCDs) that frequently accompany the aging process. All of this implies an enormous challenge for the whole of society, and that is why it is necessary to ensure that the aging process runs by the healthiest way possible. These diseases are responsible for millions of deaths, which have come to constitute more than 60% of all causes of death, with a tendency to increase by 17% in 2025 [3]
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