Abstract
A single oral dose of calcium pentosan polysulphate (10 mg/kg) induced a mean net increase in tissue-type plasminogen activator (t-PA) release of 72 ± 4.9 IU/ml plasma/h (n = 10) in male rats, aged nine weeks (CR.WIST) over 5 hours, with peak values being reached 2 hours after the administration. The mean net increase in t-PA activity amounted to 5.8 ± 1.9 IU/ml plasma/h (n = 9) (not significantly different compared with young rats) in male rats (CR:WIST), aged 52 weeks, over 5 hours, with a peak value 2 hours after administration. Sodium pentosan polysulphate (NaPPS) enhanced the mean net increase in t-PA activity in young rats (9 weeks, male) by only 3.8 ± 32 IU/ml plasma/h, (n = 15), a peak value being reached 2 hours after administration. In rats aged 52 weeks (male) the mean net increase in t-PA activity measured every hour (3.5 ± 1.9 IU/ml plasma; n = 8) was similar to that measured in young rats. Compared to NaPPS, CaPPS enhanced the net t-PA activity by about 50% in young rats aged 9 weeks.
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