Age-dependent associations of risk factors for cardiovascular diseases with the state of cognitive functions

Abstract

The aim of the study was to provide a population assessment of cognitive impairment patterns in a representative sample of 25–44 year old men and women living in Western Siberia with metabolic syndrome (MS). The aim of the study is to study the features of the interrelationships of conventional and nonconventional risk factors for cardiovascular diseases (RF CVD), molecular genetic markers with the state of cognitive functions (CF), objective–subjective index of CF in an open population in persons aged 14–17, 25–44 years (Novosibirsk).Material and methods: A singlestage population survey of a random representative sample of 25–44 year olds of both sexes (1503 people) permanently residing in Western Siberia (Novosibirsk) was performed. The study of the state of cognitive functions was conducted in 1009 people: 463 men (45.9 %) and 546 women (54.1 %). The object of the study was random representative samples of the population of Novosibirsk, formed during the screenings of the NIITPM branch of the ICIG SB RAS. The paper uses materials from a one-stage population survey of adolescents (screenings 2009–2010 and 2019) and persons aged 25–44 years (screening 2013–2016). According to the methods standardized during the screening, the following were performed: a 10-word memorization test, a proof-reading test, and a concept exclusion test. Anthropometric measurements were carried out. Determination of the levels of lipid fractions was carried out according to standardized methods. Genotyping of rs2464196 HNF1A and rs11212617 ATM was carried out using real-time PCR.Results. In the examined samples of Novosibirsk residents aged 14–17 and 25–44 years, statistically significant negative associations of RF CVD with neurodynamic CF were observed. Proatherogenic conventional RF CVD had a negative impact on attention and thinking patterns (among the most significant were the content of total cholesterol (odds ratio (OR) 0.996; 95 % confidence interval (95 % CI) 0.993–1,000; p = 0.043), low density lipoprotein cholesterol (OR 0.994; 95 % CI 0.990–0.998; p = 0.002)). The factors reducing the risk of deterioration of CF in 25–44 year olds were the presence of higher education (OR 2,350; 95 % CI 1,442–3,828; p = 0.001), female (OR 2,068; 95 % CI 1,552–2,754; p < 0.0001). In the cohort analysis, it was revealed that the studied conventional RF CVD undergo statistically significant changes in the direction of their increase during adulthood over the past 5 years (p < 0.05). It was shown that metabolic syndrome (MS) occurred in every fourth person tested for CF (26.06 %), while the values of cognitive tests were higher in people without MS compared to those who were diagnosed with MS (p < 0,05). Smoking had a negative effect on the memory pattern, causing a deterioration in the memorization of words (OR 1,071; 95 % CI 1,012–1,133); (p = 0.017). The deterioration of memory, attention and thinking patterns in the presence of workplace stress and low professional status, – important unconventional RF CVD, – has been established (p < 0.05)).Conclusion. In the open population of adolescents and young people (25–44 years old), a statistically significant deterioration of cognitive patterns was found in the presence of the studied conventional and non-conventional RF CVD.