Abstract
The age-specific impact on the survival of gastric cancer patients with distant metastasis is still unclear. In this study, we identified 11, 299 gastric cancer patients with distant metastasis between 2004 and 2013 from Surveillance, Epidemiology, and End Results population-based dataset. Patients were divided into young (≤60) and elderly groups (>60). Kaplan-Meier methods and multivariable Cox regression were used for the analysis of long-term survival outcomes and risk factors. There were significant differences between the two groups in terms of race, primary site, grade, histologic type, surgery, marital status and clinical T stage (P<0.05). The 1- and 3-year cancer specific survival rates were 29.0% and 6.2% in young group and 22.8% and 4.8% in elderly group in both univariate (X2=116.430, P<0.001) and multivariate analysis (P<0.001). Young patients had significantly better 1- and 3-year cancer specific survival than elderly patients in each T stage. Age was further validated as an independent survival factor in all T stages (T1, T2, T3, T4 and TX, P<0.05). In conclusion, age was an independent prognostic factor for gastric cancer patients with distant metastasis.
Highlights
Gastric cancer (GC) is the fifth most common malignancy worldwide and the third leading cause of cancer deaths [1,2,3]
Song et al [8] argued that the prognosis of GC varied with age, and young patients had a higher survival rate after surgery compared to elderly patients
Despite advancement of diagnosis and treatment of GC, the prognosis remains poor with a 5-year overall survival (OS) of less than 30% in most countries [4,5, 14]
Summary
Gastric cancer (GC) is the fifth most common malignancy worldwide and the third leading cause of cancer deaths [1,2,3]. Despite the improvements in diagnosis and treatment, the 5-year overall survival (OS) rate for advanced GC is still below 30% [4,5]. Song et al [8] argued that the prognosis of GC varied with age, and young patients had a higher survival rate after surgery compared to elderly patients. Similar results were found in Li's study [6], where young patients with colorectal cancer after surgery had a higher cancer specific survival (CSS) rate than elderly ones [6]. We compared the pathological characteristics and prognostic outcomes of GC with M1 in young patients www.impactjournals.com/oncotarget with elderly ones based on Surveillance, Epidemiology, and End Results (SEER) population-based data
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