AGE-SPECIFIC FEATURES OF ISNULIN-LIKE GROWTH FACTOR 1, ITS BINDING PROTEIN 3, AND CARBOHYDRATE HOMEOSTASIS IN PATIENTS WITH COLORECTAL CANCER

Abstract

Aim. The aim of our study was to study of age-specific features of IGF-1, IGF BP3, and carbohydrate homeostasis in patients with colorectal cancer. Methods: The study and control groups consisted of 50-50 participants, who were divided into three age groups, Group 1 (30-55 yrs.); Group 2 (55-65 yrs.); Group 3 (>65 yr.). IGF-1, IGF BP3, Serum insulin and glucose levels were performed. Results: The mean IGF-1 values for the age groups were as follows: study group S1 (35-55 yrs.) - 214.5 ± 23.0; study group S2 (55-65 yrs.) - 202.5 ± 15.5; study group S3 (> 65 yr.) - 190.5 ± 22.0; control group C1 (35-55 yrs.) - 162.3 ± 31.7; control group C2 (55-65 yrs.) - 150.6 ± 35.7; control group C3 (> 65 yr.) - 146.1 ± 32.4. The mean IGF BP3 values for the age groups were as follows: study group S1 (35-55 yrs.) - 2.0 ± 0.7; study group S2 (55-65 yrs.) - 1.6 ± 0.3; study group S3 (> 65 yr.) - 1.7 ± 0.6; control group C1 (35-55 yrs.) - 3.6 ± 1.0; control group C2 (55-65 yrs.) - 3.9 ± 1.0; control group C3 (> 65 yr.) - 3.6 ± 0.9. Conclusion. Age-dependent features of the IGF-system have been reported in patients with colorectal cancer. Moreover, in all age groups of CRC patients, despite the nature of the change of IGF-1 and IGF BP3, a inverse association was maintained between these parameters. However, the concentration of sex-adjusted IGF-1 in the lower age group is significantly low compared to the old age group.