Abstract
A global effort is currently undertaken to restrain the COVID-19 pandemic. Host immunity has come out as a determinant for COVID-19 clinical outcomes, and several studies investigated the immune profiling of SARS-CoV-2 infected people to properly direct the clinical management of the disease. Thus, lymphopenia, T-cell exhaustion, and the increased levels of inflammatory mediators have been described in COVID-19 patients, in particular in severe cases1. Age represents a key factor in COVID-19 morbidity and mortality2. Understanding age-associated immune signatures of patients are therefore important to identify preventive and therapeutic strategies. In this study, we investigated the immune profile of COVID-19 hospitalized patients identifying a distinctive age-dependent immune signature associated with disease severity. Indeed, defined circulating factors - CXCL8, IL-10, IL-15, IL-27, and TNF-α - positively correlate with older age, longer hospitalization, and a more severe form of the disease and may thus represent the leading signature in critical COVID-19 patients.
Highlights
Introduction The pathophysiology of COVID19 is still a matter of scientific investigation
The disease seems to manifest itself in more or less severe forms depending on the age of the patients, with older people being at higher risk of developing serious complications[3]
Markedly high levels of interleukin IL-2R, IL-6, IL-10, and TNF-α have been reported in patients with severe illness[5], other reports suggest that more cytokines are involved in the COVID-19 pathogenesis[6,7]
Summary
Introduction The pathophysiology of COVID19 is still a matter of scientific investigation. We analyzed the cytokine and leukocyte profile of COVID-19 patients at hospital admission and identified distinctive immunological signatures that characterize younger or older severe patients. To further associate the identified cytokine profiles to the clinical evaluation, the absolute plasma concentrations of the aforementioned age-dependent and age-independent cytokines were compared in patients with different disease severity, Fig. 2 (See legend on page.) Official journal of the Cell Death Differentiation Association
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
