Abstract
The chromosome aberrations induced by various concentrations of thio-tepa and degranol have been studied in cultures of human peripheral blood from subjects of different sexes and ages: newborns, young adults (mean age 23 years) and elderly persons (mean age 70 years). The frequency of induced chromosome aberrations increased with age after treatment with either agent. The higher the mutagen dose the greater the age difference in chromosome aberration frequency. Most aberrations induced by the two agents in cells from all age groups were of the chromatid type. The observed distribution of aberrations among the chromosomes differed from a theoretical distribution based on the length of chromosomes at metaphase. After treatment with thio-tepa the deviation was the same in all the age groups, but after treatment with degranol the deviation differed somewhat in the investigated groups.
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