Abstract
Age-related alterations of serotonin (5-hydroxytryptamine; 5-HT) type 2A receptors (5-HT 2A) in the living brains of young (6.0±1.3 years old) and aged (19.2±3.0 years old) monkeys ( Macaca mulatta) were evaluated with [ 11C]MDL100,907 in the conscious state using high-resolution positron emission tomography (PET). For quantitative analysis of 5-HT 2A binding in vivo, PET scan of [ 11C]MDL100,907 was performed with arterial blood sampling in each animal, and the metabolic-corrected arterial input function was used for Logan graphical analysis. Higher cerebral binding of [ 11C]MDL100,907 was observed in the hippocampus, cingulate gyrus, frontal, temporal and occipital cortices, regions known to contain high densities of 5-HT 2A, by in vitro assay. Binding was intermediate in the striatum and thalamus, and lower in the pons and cerebellum in both young and aged monkeys. The age-related decrease in [ 11C]MDL100,907 binding to 5-HT 2A receptors was prominent in the hippocampus, cingulate gyrus, frontal, temporal and occipital cortices, but not in the striatum, thalamus and pons. These observation demonstrated the usefulness of [ 11C]MDL100,907 as an labeled compound for assessment of the aging process of the cortical 5-HT 2A measured by PET.
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