Age-Related Prostate Specific Antigen Reference Ranges in Healthy Northern Iranian Men.

Abstract

Prostate cancer is the third most common malignancy in men worldwide. Despite being a helpful biomarker in prostate cancer, prostate specific antigen (PSA) is affected by different factors including age, lifestyle, geographical region and ethnicity. To determine the age specific serum PSA level among healthy Northern Iranian men and to compare the results of our study with the findings of other populations in the world. A total of 1271 men who were referred for routine check-up in a multispecialty hospital in the city of Rasht, in Northern Iran, were evaluated for their PSA levels by commercial ELISA method. The normal age related prostate specific antigen range (0-95th percentile) in our study was 0.0-0.62 in men younger than 40 yrs; 0.0-0.75 ng/ml in 40-49 yrs; 0.0-0.91 ng/ml in 50-59 yrs; 0.0-1.33 ng/ml in 60-69 yrs; 0.0-1.45 ng/ml in 70-79 yrs group and 0.0-1.93 in subjects older than 80 yrs. The present study revealed the lowest upper limit of PSA level in all age groups in comparison to populations from different countries.