Abstract
Like other sensory systems, olfactory function deteriorates with age. Epidemiological studies have revealed that the incidence of olfactory dysfunction increases at the age of 60 and older and males are more affected than females. Moreover, smoking, heavy alcohol use, sinonasal diseases, and Down’s syndrome are associated with an increased incidence of olfactory dysfunction. Although the pathophysiology of olfactory dysfunction in humans remains largely unknown, studies in laboratory animals have demonstrated that both the peripheral and central olfactory nervous systems are affected by aging. Aged olfactory neuroepithelium in the nasal cavity shows the loss of mature olfactory neurons, replacement of olfactory neuroepithelium by respiratory epithelium, and a decrease in basal cell proliferation both in the normal state and after injury. In the central olfactory pathway, a decrease in the turnover of interneurons in the olfactory bulb (OB) and reduced activity in the olfactory cortex under olfactory stimulation is observed. Recently, the association between olfactory impairment and neurodegenerative diseases, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), has gained attention. Evidence-based pharmacotherapy to suppress or improve age-related olfactory dysfunction has not yet been established, but preliminary results suggest that olfactory training using odorants may be useful to improve some aspects of age-related olfactory impairment.
Highlights
Olfaction is a sense that allows the detection of odors in the surrounding environment
Suzukawa et al (2011) evaluated age-related changes in neuroepithelial regeneration after chemical injury in mice and demonstrated that: (1) the chronological pattern in neuronal cell proliferation and differentiation was similar among the different age groups; (2) the extent of neuroepithelial cell proliferation after injury decreased with age; and (3) the final histological recovery of the olfactory neuroepithelium and the innervation of the olfactory bulb (OB) was significantly lower in the aged group than in younger age groups
These results suggest that the age-related decline in olfactory neuroepithelial regeneration capacity is associated with a decreased proliferative activity, rather than with changes in the neuronal differentiation process
Summary
Olfaction is a sense that allows the detection of odors in the surrounding environment. Several pathoetiologies, including chronic rhinosinusitis, viral infection, head trauma, and intake of toxic drugs are associated with the development of olfactory dysfunction (Hummel et al, 2017) Along with these pathologies, age is one of the most important factors associated with human olfactory dysfunction (Schiffman, 1997; Brämerson et al, 2007; Doty and Kamath, 2014; Mobley et al, 2014; Attems et al, 2015). While there has been rapid progress in understanding the molecular mechanisms mediating olfaction (Ihara et al, 2013; Takeuchi and Sakano, 2014), the pathogenetic processes underlying age-related human olfactory dysfunction, and, in particular, the changes in the olfactory neural system, remain largely unknown. This review article, aimed to shed light on age-related changes occurring in the olfactory neural system during olfactory deterioration, both within the context of the normal aging process and under pathological conditions
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
