Abstract
BackgroundNumerous studies have reported that age-induced increased parathyroid hormone plasma levels are associated with cognitive decline and dementia. Little is known about the correlation that may exist between neurological processing speed, cognition and bone density in cases of hyperparathyroidism. Thus, we decided to determine if parathyroid hormone levels correlate to processing speed and/or bone density.MethodsThe recruited subjects that met the inclusion criteria (n = 92, age-matched, age 18-90 years, mean = 58.85, SD = 15.47) were evaluated for plasma parathyroid hormone levels and these levels were statistically correlated with event-related P300 potentials. Groups were compared for age, bone density and P300 latency. One-tailed tests were used to ascertain the statistical significance of the correlations. The study groups were categorized and analyzed for differences of parathyroid hormone levels: parathyroid hormone levels <30 (n = 30, mean = 22.7 ± 5.6 SD) and PTH levels >30 (n = 62, mean = 62.4 ± 28.3 SD, p ≤ 02).ResultsPatients with parathyroid hormone levels <30 showed statistically significantly less P300 latency (P300 = 332.7 ± 4.8 SE) relative to those with parathyroid hormone levels >30, which demonstrated greater P300 latency (P300 = 345.7 ± 3.6 SE, p = .02). Participants with parathyroid hormone values <30 (n = 26) were found to have statistically significantly higher bone density (M = -1.25 ± .31 SE) than those with parathyroid hormone values >30 (n = 48, M = -1.85 ± .19 SE, p = .04).ConclusionOur findings of a statistically lower bone density and prolonged P300 in patients with high parathyroid hormone levels may suggest that increased parathyroid hormone levels coupled with prolonged P300 latency may become putative biological markers of both dementia and osteoporosis and warrant intensive investigation.
Highlights
Numerous studies have reported that age-induced increased parathyroid hormone plasma levels are associated with cognitive decline and dementia
While numerous studies have reported that age-induced increased parathyroid hormone (PTH) plasma levels are associated with cognitive decline [1] and dementia [2,3], little is known about the correlation that may exist between neurological processing speed and bone density in cases of hyperparathyroidism or elevated PTH
The following paragraphs describe the outcomes of the tests of normality, the correlational analyses, and the analyses of differences between the levels of the dichotomized forms of PTH and Bone Mineral Density (BMD)
Summary
Numerous studies have reported that age-induced increased parathyroid hormone plasma levels are associated with cognitive decline and dementia. Little is known about the correlation that may exist between neurological processing speed, cognition and bone density in cases of hyperparathyroidism. While numerous studies have reported that age-induced increased parathyroid hormone (PTH) plasma levels are associated with cognitive decline [1] and dementia [2,3], little is known about the correlation that may exist between neurological processing speed and bone density in cases of hyperparathyroidism or elevated PTH. Recombinant human PTH 1-34 (teriparatide) is being used as a treatment for osteoporosis, and its administration has been shown to stimulate bone formation and increase bone mineral density [8]. There has not yet been any published research on teriparatide administration for hyperparathyroidism-induced osteoporosis
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