Abstract
Activities of total alkaline phosphatase (TALP) and its bone isoform (BALP) was greater in groups of children and adolescents in the late posttraumatic period (pattern of reparative bone remodeling) and scoliosis (pathological bone remodeling), than in the control (healthy children and adolescents). The content of collagen type I degradation products (CrossLaps) peripheral blood practically was unchanged. Examined group with posttraumatic period had high activity of tartrate-resistant acid phosphatase form (TRACP). TALP activity reached minimum values in all the studied groups. In the process of children growing to 15–18 years old, as compared to 7–10 years old, reducing activity of remodeling was observed under physiological (healthy donors) and reparative osteogenesis. It’s changes was recorded by significant decrease of the studied indicators. On the contrary, children 15–18 years old with scoliosis had maximum of the imbalance (activation/inhibition of various signs of osteogenesis) of resorptive/synthetic bone processes. Also, for this group we discovered decrease osteocalcin concentration of 4 times in comparison with the group children of 7–10 years old. The detected growth of the correlations number in the correlation matrix of bone remodeling markers in case of scoliosis proposes the reduction of adaptation reserve of 15–18 years old adolescents, suffering from dysplasia of connective tissue. Thus, the pathophysiological and clinical significance of distant markers of bone metabolism screening in peripheral blood the is ambiguous. The interpretation of these indicators is difficult and largely depends on the clinical situation and age of patients. This requires improving the diagnostic approach to assess physiological and pathological remodeling of bone tissue by means of biochemical blood indicators.
Highlights
Health Organization Fracture Risk Assessment Tool (FRAX): what they mean to the bone densitometrist and bone technologist // Journal of Clinical Densitometry. 2008
Оригинальные статьи children 15–18 years old with scoliosis had maximum of the imbalance of resorptive/synthetic bone processes. For this group we discovered decrease osteocalcin concentration of 4 times in comparison with the group children of 7–10 years old
The pathophysiological and clinical significance of distant markers of bone metabolism screening in peripheral blood the is ambiguous
Summary
Кость – это активно функционирующая система, в которой постоянно протекают сопряженные процессы резорбции и формирования внеклеточного матрикса, причем слаженная работа компонентов ремоделирования зависит от физической нагрузки, гендерных и возрастных факторов [1, 2, 3]. Дисбаланс системы ремоделирования может возникать как вследствие нарушений молекулярно-клеточной кооперации процессов резорбции и регенерации костной ткани, так и по причине нарушения функционирования регуляторных систем организма [1]. Манифестация патологических изменений костной ткани в детском и подростковом возрасте минимальна в силу интенсивного роста скелета, обусловленного преобладанием процессов формирования костей над их резорбцией [5, 6, 7, 8]. Богатая васкуляризация развивающегося скелета позволяет провести оценку соотношения эффекторных компонентов ремоделирования (лизис и (или) синтез) кости по дистантным маркерам в периферической крови. Цель – провести анализ молекулярных показателей периферической крови [12, 13, 14], свидетельствующих об активности резорбции (опосредована остеокластами) и (или) формирования (опосредована остеобластами) костной ткани у детей и подростков различных клинических и возрастных групп
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