Age-related changes of β-adrenoceptors in spleen lymphocytes and cerebral cortex of NZB/BIN mice

Abstract

The density (B max) of β-adrenoceptors in splenic lymphocytes of NZB/BIN mice decreased up to an age of about 40 weeks and then levelled out. The B max in cerebral cortex, on the other hand, increased in the first half of life and then changed relatively little. The dissociation constant of the ligand ( K d) was larger in the cortex than the spleen and showed relatively little age-dependent change.