Abstract
www.ClinicalTrials.gov, identifier NCT01066377.
Highlights
Influenza vaccination offers an important prophylactic solution for preventing infection and associated complications, but immunosenescence significantly impairs vaccine efficacy [1]
This study investigated the effect of a novel probiotic, Bifidobacterium longum bv. infantis CCUG 52486, combined with a prebiotic, gluco-oligosaccharide (B. longum + Gl-OS), on the Natural killer (NK) cell response to seasonal influenza vaccination in young and older subjects in a double-blind, randomized controlled trial
Natural killer (NK) cells and NKT cells are an important component of the immune response to influenza infection and low NK activity may be related to higher infection risk [3]
Summary
Influenza vaccination offers an important prophylactic solution for preventing infection and associated complications, but immunosenescence significantly impairs vaccine efficacy [1]. Natural killer (NK) cells and NKT cells are an important component of the immune response to influenza infection and low NK activity may be related to higher infection risk [3]. Studies examining the adjuvant effects of probiotics on the immune response to vaccination have focused exclusively on adaptive immunity, but this could be indirectly affected by NK cells. In support of this concept, administration of the probiotic, Lactobacillus casei Shirota, and Lactobacillus rhamnosus, protected mice from intranasally administered influenza virus infection at least partly by enhancing NK cell activation in the lung [24, 25].
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