Abstract
Results from our studies indicate that aged rats exhibited greater sensitivity to punctate mechanical nociceptive stimulation than young rats. The present studies were designed to further explore the mechanism underlying the age-related increase in sensitivity and sensitization to punctate mechanical nociceptive stimulation and determine the involvement of NR1 in these effects. Activation of the NMDA receptor is integral to the initiation and maintenance of central sensitization whereby nociceptive activity is enhanced.
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