Abstract
The present study used positron emission tomography (PET) with [15O]H2O to examine age-related differences in regional cerebral blood flow (rCBF) among healthy adults in early to mid-adulthood. The characterization of age-related changes in baseline rCBF is relevant to the interpretation of flow differences during cognitive activation tasks and facilitates the understanding of aging effects on brain function. The authors examined 37 healthy volunteers ranging in age from 19 to 50 years. PET images were obtained during an eyes-closed resting baseline condition. The authors observed a significant negative correlation between age and rCBF in the right hippocampal region (r=−0.63, P<0.001) as well as a negative correlation between age and rCBF in mesial frontal cortex (r=−0.67, P<0.001). No significant correlation was observed between whole brain blood flow and age (r= −0.17). These findings may reflect subtle regional differences in cerebral blood flow occurring from early to mid-adulthood that may be associated with changes in memory and executive function manifesting in late life. The absence of an age-related decrease in whole brain flow suggests that some regions may be preferentially affected earlier than others. P30
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