Year-end Sale % OFF 
Abstract
Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on gait was studied in young (4 weeks) and old (21 months) male rats. No significant alteration in stride length (SL) or stride width (SW) was observed 30 min after single dose MPTP treatment (3 mg/kg, i.p.) in both young and old rats. Multidose treatment with MPTP (3 mg/kg, i.p. daily for 8 days) resulted in a marked decrease in SL in old rats compared to that of old control group, while an increase in SL was found in both MPTP-treated and control young rats. In contrast, multidose MPTP administration caused no changes in SW in either young or old rats. The present result of behavioral analysis suggests that multidose MPTP neurotoxic effect on locomotor activity may be age dependent in rats and that the old rat is an appropriate model for MPTP studies.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
