Abstract
The non-induced levels of hepatic microsomal NADPH cytochrome c reductase and cytochrome P-450 undergo marked age-dependent declines in male Fischer 344 rats, especially between maturity and senescence. Phenobarbital administration causes significant increases in these two parameters in young and (1 month) and mature (16 months) animals, but not in senescent rats (27 months). Both the rates of enzyme and haemoprotein induction and the maximum-induced levels achieved after six days of drug treatment are significantly greater in the young and mature animals vs the senescent rats. These functional data correlate reasonably well with [1] a similar age-dependent response of microsomal protein concentration to phenobarbital administration and [2] the quantitative morphological evidence demonstrating an age-related loss in the amount of hepatic smooth-surfaced endoplasmic reticulum between maturity and senescence.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
