Abstract
AbstractSeveral definitive statements concerning the effect(s) of animal age on liver drug metabolism are made, and at the same time certain crucial questions that remain to be resolved are posed. Between 16 and 30 months of age, or maturity and senescence, the male Fischer rat exhibits a significant loss of hepatic smooth-surfaced endoplasmic reticulum (SER) which constitutes a real quantitative change. However, this does not exclude the possibility of qualitative age-related changes in this membrane, such as compositional alterations which may be reflected in its functional integrity. Second, there is a significant decline in the noninduced activities or amounts of enzymes and hemoproteins, respectively, of the microsomal mixed function oxidase system. With the exception of the loss of cytochrome P-450, which represents a quantitative change, the age-dependent alterations in the two enzymes may reflect quantitative and/or qualitative changes. Last, the reduced hepatic responsiveness to phenobarbital is ...
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Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
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