Abstract
Introduction: Aging is an important risk factor for the development of many chronic illnesses and is the biggest risk factor for ischemic stroke. Initial experimental observations into the role of aging on stroke outcomes revealed that while aged mice have significantly smaller brain infarct volumes compared to young mice, they have higher mortality and long-term deficits in behavioral recovery. Although normal aging is associated with profound changes in the peripheral immune compartment it is unclear how these changes influence the response to stroke injury.
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