Abstract
1. 1. Age-related changes in glutathione (GSH) content of eye lenses were investigated in senescenceaccelerated mouse (SAM) and C57BL/J mice. 2. 2. The decrease of GSH content with aging is markedly observed in SAM strains. 3. 3. The oxidized glutathione (GSSG) content of eyes increased significantly with aging in SAM. 4. 4. Ophthalmic changes, including cataract, increased with age in SAM alone. 5. 5. The decrease of GSH content and the increase of GSH oxidation may be involved in the pathogenesis of cataract in SAM.
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Schedule a callMore From: Comparative Biochemistry and Physiology Part A: Physiology
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