Abstract
Age-related changes in novelty detection for object–place associations was assessed in 6-mo and 25-mo-old Fisher 344/Brown Norway (F344/BN) rats. Old rats showed significant deficits compared to young rats in detecting spatial displacement of objects. The data suggest that object–place novelty detection is impaired in aged F344/BN rats using a rapidly acquired, exploratory-based task. The results may have important implications for the selection of efficient memory paradigms for future aging studies.
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