Abstract
Acute application of different pattern transcranial magnetic stimulation (rTMS) upon motor cortex of rats: intermittent theta-burst stimulation (iTBS) in order to induce neuronal facilitation, continuous theta-burst stimulation (cTBS) anticipating inducing inhibitory effects. Single protocol of given stimulation was applied on motor cortex of four groups of 8 and 4 weeks old Wistar male rats: control; placebo, iTBS and cTBS. Reduced glutathione (GSH) and total sulphidriles (tSH) were measured in hippocampus, 24 h after single treatment, tSH were measured in plasma at the same time point. In young, as well as in old animals, 24 h post treatment, SH in plasma were unchanged compared with control or placebo group. In hippocampus of old animals, GSH was on control level in all experimental groups, while tSH decreased in iTBS group, compared to controls ( p p Obtained results point up on age related different pattern of metabolic changes in hippocampus, distant from the place of rTMS application. Improved GSH and SH groups metabolism in single iTBS treated young animals direct to beneficial effect of iTBS in this age, which is different from changes in acutely treated old animals.
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