Age of women, the AMH level and the number of oocytes has co-related with aneuploidy ratios as preimplantation genetic screening indicator

Abstract

To identify the relationship between age, AMH, the number of oocytes a woman has and the PGS outcome. This is a retrospective study. We analyzed our center’s IVF outcome data from January 1-2016 to October 31-2017. We had a total case number of 303 IVF cases with PGS and AMH data. We collected the PGS analysis data with a patient with an AMH level. Then we statistically analyzed its co-relationship of PGS data with age, AMH level and the number of oocytes. We compared clinical data between all abnormal PGS cases and normal cases. All data were analyzed through SPSS statistics. We In the case of age, the low AMH group and 35 ∼ 39 age group had a significantly high aneuploidy ratio, compared to the group with high AMH levels. Based on the number oocytes, the age group of those over 40 years old (≥40) had more than ten oocytes that showed a significantly high normal PGS outcome, compared to those with a low number of oocytes. Even a patient(s) in the young age group with low AMH (35-39, AMH ≤ 2.33) could need a recommendation in PGS to select a normal embryo. Therefore, the old age group with a high number of oocytes (age ≥35, the number of oocytes ≥10) wouldn’t be as recommended for PGS than those patients who harvested a low number of oocytes. Some specific factors have a certain effect to aneuploidy ratios of embryos depending on its age, the AMH level and the number of collected oocytes. PGS is a good tool for selecting an embryo with a normal chromosome. However, we need a critical recommendation guideline for patients. Our study may help in setting up the criteria guideline of PGS.Tabled 1Table 1PGS outcome in relation to AMH level and the number of oocytesPGS OutcomeAMHOOCYTE NO.≤3435-39≥40≤3435-39≥40ALL ABNORAML6.07±2.92.33±1.6*2.00±1.513.42±7.19.20±5.0*6.60±4.4*NORMAL6.23±5.73.51±2.3*2.51±1.715.94±9.315.06±8.8*11.32±5.0*p vaule0.9420.0270.0640.5060.0000.000 Open table in a new tab