Age macular degeneration: clinical, biological, morphologic, structural biomarkers for neovascular complication

Abstract

PurposeTo determine clinical, biological, morphologic, structural elements as biomarkers for AMD Neovascular complicationMethodsAMD:114 AMD patients, with AMD Neovascular complication. Ophthalmologic exam included ETDRS visual acuity, complete ophthalmic examination, Fundus examination, Multimodal imaging:autofluorescence imaging (FAF),optical coherence tomography (Spectralis HRA‐OCT),OCTenFace, Morphology‐Structural software (M‐S),Fluorescein Angiography, ICG. Cognitive evaluation is done for all of them with MMSE:Mini Mental State Examination (Folstein, GRECO),score let determine various groups, subgroups. Lipidomic Study:Blood tests and analysis, all lipids qualitative, quantitative analysis, all the same for 10 of those 114 patients. Blood test is done during ophthalmologic exam. Plasma congelation ‘snap frost’ after total blood centrifugation, then liquid‐liquid extraction for lipids analysis:neutral lipid, fatty acid, phospholipids, as sphingolipids, Polyinsatured fatty acids tooResultsMMSE:35% Normal score,62% MCI cases (mild MCI (47%),moderate MCI (35%)),3% early stage AD, cognitive function is rather spared but early AD. Lipidomics:High levels for each and most of lipids, higher/highest for Free, Total Esterified Cholesterol, TxB2,13‐HODE,9‐HODE,12‐HETE, MUFA/PUFA, highest for Eicosanoids, Fames TotalFattyAcid, more/less Phospholipids (PC).Results are effective, statistically significative. Multimodal imaging, M‐S:more, mostly drusenoids deposits Protein‐Cellular type, ‘P’, individualized, presents, underlined. So, those results, elements become and are Biomarkers for AMD Neovascular complication, allow better AMD follow‐up and etiopathogeny understandingConclusionsEach clinical, biological, multimodal entity, all, together or not, are Biomarkers, allow AMD screening, follow‐up, particularly AMD Neovascular complication. They also lead to better etiopathogeny understanding and therapeutics prospects.