Abstract
Objective: Analysis of ultrastructure of a biomineral of hip bones (HB) in white rats in alimentary obesity caused by excessive refined palm oil (PO) intake as well as developing a method for correction of detected changes using Garcinia cambogia extract (GCE).Methods: 216 male rats (juvenile, pubertal, and senile) were used. Animals received PO at a dose of 30 g/kg a day and GCE at a dose of 0.25 g/kg a day 6 weeks later after the start of PO intake. The ultrastructure of PO biomineral was analyzed by X-ray scattering technique.Results: When juvenile rats took PO, the sizes of crystallites were 4.35% larger than control figures by the 60th day, and coefficient of micro-texturing was 4.72% lower. In pubertal rats, these deviations were 6.14 and 5.05%; in senile rats, they were 5.68 and 7.43%, respectively. When administrating GCE, in juvenile rats, the sizes of crystallites were 3.82% lower than values of group without correction by the 60th day, and coefficient of micro-texturing was 4.67% higher. In pubertal rats, these deviations accounted for 5.52 and 8.03%; and in senile rats, they were 4.34 and 5.56%, respectively.Conclusion: Consumption of PO at a dose of 30 g/kg a day is accompanied by destabilization of HP biomineral in white rats. Administration of GCE at a dose of 0.25 g/kg a day reduces the effect of PO on the ultrastructure of HB biomineral from 30 to 60 days in juvenile and pubertal rats, in senile rats – from the 60th day.
Highlights
Analysis of ultrastructure of a biomineral of hip bones (HB) in white rats in alimentary obesity caused by excessive refined palm oil (PO) intake as well as developing a method for correction of detected changes using Garcinia cambogia extract (GCE)
В итоге снижается уровень неспецифического воспаления, развивающегося при ожирении, что в нашем случае приводило к восстановлению процессов нуклеации элементарных ячеек биоминерала тазовых костей и формированию стабильной кристаллической решетки
Внутрижелудочное введение экстракта гарцинии камбоджийской в дозе 0,25 г/кг в сутки нивелирует негативное влияние условий эксперимента на ультраструктуру кристаллической решетки биоминерала тазовой кости с 30-х по 60-е сутки наблюдения у ювенильных и половозрелых животных и с 60-х суток – у крыс старческого возраста
Summary
При приеме ПМ у ювенильных крыс к 60-м суткам размеры кристаллитов были больше контроля на 4,35 %, а коэффициент микротекстурирования – меньше на 4,72 %. При введении ЭГК у ювенильных крыс к 60-м суткам размеры кристаллитов были меньше значений группы без коррекции на 3,82 %, а коэффициент микротекстурирования – больше на 4,67 %. У половозрелых крыс эти отклонения составили 5,52 и 8,03 %, а у сенильных 4,34 и 5,56 %, соответственно. Введение ЭГК в дозе 0,25 г/кг в сутки сглаживает влияние ПМ на ультраструктуру биоминерала ТК с 30-х по 60-е сутки у ювенильных и половозрелых и с 60-х суток – у сенильных крыс. Возрастные особенности ультраструктуры биоминерала тазовой кости у белых крыс при избыточном содержании в рационе пальмового масла и введении экстракта гарцинии камбоджийской.
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