Abstract

Study objective. To establish clinical and epidemiological features of intestinal amebiasis in adults and children at the present stage. A retrospective analysis of patient histories of 90 cases of intestinal amebiasisin patients aged 3 to 40 years who were on inpatient treatment in Regional Infectious Clinical Hospital named after A.M Nichogi, Astrakhan, in the period from 2014 to 2017. The diagnosis of amebiasis was confirmed by microscopy of feces, detection of antibodies by using reaction of indirect hemagglutination (RHAG) with a specific antigen, determination of DNA of the parasite by polymerase chain reaction (PCR).Results. It was determined that the incidence of intestinal amebiasis in the Astrakhan region is sporadic with the involvement in the epidemic process of persons of working age from 18 to 40 years (75.6%) and children aged 3 to 10 years (24.6%) of organized groups living in the city. Acute intestinal amebiasis in 86.8% of adults proceeded in mild to moderate form. The clinical course of the disease was characterized by a gradual onset in 82.4%, mucosal-bloody stool in 94.1%, the outcome of a chronic recurrent form in 11.8%. Raspberry jelly-like stool, extraintestinal complications of amebiasis, characteristic of amebiasis of previous years, were absent.The features of intestinal amebiasis in children were: acute onset of the disease in 63.6%, fever 38°C and above in 54.5%, abdominal pain in 95.5%, prolonged diarrhoea with a stool frequency of more than 10 times in 72.7%, stool with blood mucus in 95.5%, tenesmus in 36.4%, dehydration in 18.6% of patients. The mild form of the disease in children was not observed, severe was observed in 54.5%, moderate in 45.5%. The combined course of intestinal amebiasis with bacterial dysentery, proceeded more severely, changed clinical symptoms of the disease, made it difficult to diagnose amebiasis in a timely manner.

Highlights

  • Цель исследования: установить клинико-эпидемиологические особенности амебиаза кишечника у взрослых и детей на современном этапе

  • A retrospective analysis of patient histories of 90 cases of intestinal amebiasis in patients aged 3 to 40 years who were on inpatient treatment in Regional Infectious Clinical Hospital named after A.M Nichogi, Astrakhan, in the period from 2014 to 2017

  • The diagnosis of amebiasis was confirmed by microscopy of feces, detection of antibodies by using reaction of indirect hemagglutination (RHAG) with a specific antigen, determination of DNA of the parasite by polymerase chain reaction (PCR)

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Summary

Age features of intestinal amoebiasis

Astrakhan State Medical University of the Ministry of Health of the Russian Federation, Astrakhan, Russia. Цель исследования: установить клинико-эпидемиологические особенности амебиаза кишечника у взрослых и детей на современном этапе. Проведен ретроспективный анализ историй болезни 90 случаев амебиаза кишечника у пациентов в возрасте от 3 до 40 лет, находившихся на стационарном лечении в Областной инфекционной клинической больнице им. Особенностями кишечного амебиаза у детей являлись: острое начало заболевания у 63,6%, лихорадка до 38°С и выше у 54,5%, боли в животе у 95,5%, длительная диарея с частотой стула более 10 раз у 72,7%, стул со слизью с кровью у 95,5%, тенезмы у 36,4%, дегидратация у 18,6% пациентов. To establish clinical and epidemiological features of intestinal amebiasis in adults and children at the present stage. The features of intestinal amebiasis in children were: acute onset of the disease in 63.6%, fever 38°C and above in 54.5%, abdominal pain in 95.5%, prolonged diarrhoea with a stool frequency of more than 10 times in 72.7%, stool with blood mucus in 95.5%, tenesmus in 36.4%, dehydration in 18.6% of patients. РОССИЙСКИЙ ВЕСТНИК ПЕРИНАТОЛОГИИ И ПЕДИАТРИИ, 2018; 63:(4) ROSSIYSKIY VESTNIK PERINATOLOGII I PEDIATRII, 2018; 63:(4)

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