Abstract
Plasma IL-6 before and 20 min after prolonged muscular exercise for 20 min at the individual aerobic/anaerobic threshold was analyzed in patients with neuromuscular diseases and in controls. Patients were assigned to the following diagnostic categories: Controls ( n=18); amyotrophic lateral sclerosis ( n=7); peripheral neuropathy ( n=6); muscular dystrophy ( n=13); mitochondriopathy ( n=3); myopathy (others) ( n=3); inflammatory myopathy ( n=6); mononeuropathy ( n=4). The concentrations of IL-6 before exercise were 5.55±0.94 pg/ml, and 6.52±0.97 pg/ml after exercise ( P=0.0001). We introduced the independent variables age, sex and diagnostic category into a stepwise multiple linear regression model. Age emerged as a significant predictor of the IL-6 ratio (IL-6 post exercise/lL-6 before exercise). The regression equation was: IL-6 ratio=0.87+0.009×age (years), R=0.33, P<0.01, simple linear regression model. All IL-1β concentrations were below the sensitivity of the assay (5 pg/ml). Concerning patients with neuromuscular diseases, the age associated increased IL-6 release after exercise could mean additional muscle damage.
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