Abstract
The effects of aging on the calcemic action of parathyroid hormone were evaluated. In the first and second studies, 1-, 8-, 12-, and 22-month-old male Wistar rats were parathyroidectomized (PTX) or thyroparathyroidectomized (TPTX), injected with parathyroid hormone and bled at 0, 3, 6, 9, and 12 h and plasma calcium determined. In the third study, 2-and 15-month-old TPTX rats were injected with parathyroid hormone and bled at 0, 1, 2, 5, 15, 30 and 120 minutes and plasma immunoreactive parathyroid hormone measured. Since the rats were prestarved, subsequent rise in plasma calcium is due primarily to the effect of parathyroid hormone on bone.
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