Age-Dependent Increase in Incidence of Staphylococcus aureus Bacteremia, Denmark, 2008-2015.

Louise Thorlacius-Ussing,Thomas Benfield,Andreas Petersen,Anders Rhod Larsen,Haakon Sandholdt

doi:10.3201/eid2505.181733

Abstract

Staphylococcus aureus bacteremia (SAB) is a major cause of illness and death worldwide. We analyzed temporal trends of SAB incidence and death in Denmark during 2008-2015. SAB incidence increased 48%, from 20.76 to 30.37 per 100,000 person-years, during this period (p<0.001). The largest change in incidence was observed for persons >80 years of age: a 90% increase in the SAB rate (p<0.001). After adjusting for demographic changes, annual rates increased 4.0% (95% CI 3.0-5.0) for persons <80 years of age, 8.4% (95% CI 7.0-11.0) for persons 80-89 years of age, and 13.0% (95% CI 9.0-17.5) for persons >90 years of age. The 30-day case-fatality rate remained stable at 24%; crude population death rates increased by 53% during 2008-2015 (p<0.001). Specific causes and mechanisms for this rapid increase in SAB incidence among the elderly population remain to be clarified.

Highlights

In support of improving patient care, this activity has been planned and implemented by Medscape, LLC and Emerging Infectious Diseases
Incidence Rates The number of patients with Staphylococcus aureus bacteremia (SAB) increased from 1,131 in 2008 to 1,731 in 2015, corresponding to a 48% increase in incidence, from 20.76 to 30.73 (IRR 1.48 [95% CI 1.37–1.59]), compared with an average annual incidence rate of 24.93 cases/100,000 person-yeras
We report a 48% increase in SAB incidence during 2008–2015

Summary

Introduction

In support of improving patient care, this activity has been planned and implemented by Medscape, LLC and Emerging Infectious Diseases. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

Objectives

Methods

Results

Conclusion