Age dependent differences in human bile acid metabolism and 7 alpha-dehydroxylation.

Abstract

It has been suggested that transformation of secondary bile acids into (co)carcinogenic compounds may have a role in the development of cancer of the large bowel. Because of age dependent differences of this disease we undertook a study of cholic and deoxycholic acid metabolism of eleven young adults (group A, 20-30 years old) and eleven elderly persons (group B, 55-75 years old) with a double isotope dilution method. Daily food intake was standardized individually and gut transit time measured with radioopaque pellets and labelled chromium chloride. The 7 alpha-dehydroxylation fractions (the ratio of deoxycholic acid input rate from the large bowel to cholic acid synthesis rate) were higher in group B (P less than 0.01) due to higher deoxycholic acid input rates (P less than 0.005), especially when individuals from both groups with rapid gut transit were compared. As contributory factor was recognized the higher fractional turnover rate of cholic acid in group B. Pool sizes and synthesis rates of cholic acid and gut transit times were similar. In group A, but not in B, gut transit times correlated with deoxycholic acid input rates (P less than 0.01). The differences in bile acid metabolism may be related to a more effective colonic absorption of deoxycholic acid in the elderly persons with a concomitant decrease of active ileal absorption of cholic acid in the elderly persons. Differences in diet or gut transit time between both groups do not seem to be the underlying mechanism.