Abstract
The concentration of insulin in the portal vein and the binding of insulin to liver plasma membrane preparations was significantly lower in 24-month-old male, Sprague-Dawley rats than in rats of the same strain which were 12-months or two-months old. These changes were consistent with earlier reports of a slower increase in liver glucokinase activity upon refeeding after fasting in the 24-month-old rats. The experiments indicate the potential importance of changes in hormone responsiveness as part of "biochemical aging." By how much and whether these age-dependent changes can be modified by diet remains to be determined.
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