Abstract
Age cutoff in lymphoma diagnosis.
Highlights
Aging is characterized by immunosenescence, decreased immune response and dysregulated coordination between inflammatory and inflammationneutralizing processes
A model of aging epigenome postulates that stochastic errors in DNA methylation maintenance during DNA replication are accumulated with aging, causing epigenetic mosaicism with restricted differentiation in affected stem cells
Epstein-Barr virus (EBV)-positive Diffuse large B-cell lymphoma (DLBCL) of the elderly is a molecularly distinct variant of DLBCL, defined as a monoclonal B-cell proliferation that occurs in patients >50 years of age without a history or clinicopathologic evidence of immunodeficiency [4]
Summary
Aging is characterized by immunosenescence, decreased immune response and dysregulated coordination between inflammatory and inflammationneutralizing processes. Epidemiological data shows that there is a significant increase of DLBCL incidence with age. The epidemiological association with DLBCL and aging is partially explained by data from Jaiswal and colleagues [2].
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