Age changes in the lipid profile of rats against experimental metabolic syndrome

Abstract

Background. Metabolic syndrome (MS) is characterized by the development of pathogenetic mechanisms that potentiate abdominal obesity and insulin resistance. Obesity is a stimulator of the synthesis of active components of adipose tissue – adipocytes (AT), which leads to numerous metabolic and hemodynamic disorders. The study of pathophysiological mechanisms based on the basis of morphometric and biochemical parameters of blood pressure, taking into account age and gender aspects, is of great topical importance. Purpose – of the study is to identify differences in the morphological and histological parameters of adipocytes against the background of the development of metabolic syndrome in animals of different ages and sexes. Materials and Methods. To achieve the goal, an experimental study was conducted on 108 white rats of the WAG/G Sto population. Each age group consisted of a control (36) and an experimental series (72), where the animals were divided by sex. The 1st group included young immature 3-month-old rats of the control (1K) and experimental (1A) subgroups. Group 2 consisted of 36 sexually mature rats aged 5–6 months, divided into 2 subgroups: control (2K) and experimental (2A). The third group consisted of 36 old rats aged 18 months, divided into the control 3K (12) subgroup (6 old females and 6 old males), and the experimental subgroup 3A – of 12 females and 12 males. Results. The hypodermic tissue of all experimental groups consists of adipocytes, the size, shape and density of which had age and gender differences. In group 1A of both subgroups, the cells had a round and oval shape and were significantly smaller in size compared to groups 2A and 3A. Adipocytes of rats have morphological changes against the background of experimental modeling of MS in taking into account age and gender aspects. It was established that in the group of old animals, hypertrophic processes prevail in BP, against the background of greatly reduced hyperplastic processes. Analyzing and comparing the size of adipose tissue cells between experimental groups 1A, 2A and 3A, the dependence of the increase in the size of adipocytes, which is related to the age of the animal, was noted. Conclusions. Experimental changes in the integrative indicators of AT of rats in the pathogenesis of MS are related to age and sex. An inversely proportional dependence of the decrease in the resistance of adipocytes as the age of the animal increases was noted. The obtained results can be designated as a biological marker that determines the development of obesity against the background of disorders of the systemic inflammatory response and insulin resistance.