AGE CHANGES IN HUMAN SKIN FROM 3 YEARS TO 75 YEARS OF AGE

Abstract

Natural aging process is reflected by gradual changes in the structure of the skin. These changes become very marked in old age. The changes in the epidermis and dermis as age advances is reflected externally as wrinkling, dryness, loss of elasticity, thinning and tendency towards purpura on minor injury. So the study is done in skin specimens by grouping the individuals in 4 age groups namely Group A (3-20yrs), Group B (21-50yrs), Group C (51-65yrs and Group D (>65yrs). The specimens were stained with Haematoxylin and Eosin stain and the changes in the thickness of the epidermis, number of Rete Pegs and the Dermo-Epidermal junction were observed. The changes in the skin appendages namely the sweat glands and the sebaceous glands were also noted. Verhoeff Van Geison Stain was done and the changes in the density and thickness of the elastic fibers and collagen fibers were noted. As the average life expectancy is increasing, the aging of skin presents a growing problem for the dermatologists. Human aging is characterized by a number of disorders like Epidermolysis bullosa and Phemphigous Vulgaris affecting the structure of the skin. So it is necessary to study the normal changes that occur in the skin as age advances which predisposes to various disorders. The study will be done among Indian population.